Priligy

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What is Priligy?

Priligy (dapoxetine) belongs to the group of drugs used to treat urological diseases. The active ingredient is dapoxetine.

The drug and its main metabolites (chemicals that are involved in metabolic processes in the body’s cells) are potent selective serotonin reuptake inhibitors.

The medication is available in tablet form.

The drug is used for the treatment of premature ejaculation in men. The pills are prescribed to patients who meet the following criteria:

• insufficient control of the onset of ejaculation;
• the latent time of intravaginal ejaculation is less than 2 minutes;
• persistent or repeated ejaculation after minimal sexual stimulation before, during, and immediately after sexual penetration, which occurs earlier than the moment desired by the patient;
• a pronounced state of stress or difficulties that arose in interpersonal relationships as a result of premature ejaculation.

This drug can be used by men aged 18-64 years.

It is used only for the treatment of patients who have been diagnosed with premature ejaculation. It’s not intended for men who want to prolong sexual intercourse, delaying the onset of ejaculation.

There are no data on the safety of use in men who have not been diagnosed with premature ejaculation.

Before you begin treatment, you should be examined by a doctor.

The mechanism of action of dapoxetine during premature ejaculation is associated with a delay of neuronal serotonin reuptake and further enhancement of the action of neurotransmitters on presynaptic and postsynaptic receptors.

How to use Priligy?

The drug is taken orally (swallowed whole with a full glass of water), regardless of food, 1-3 hours before the expected sexual intercourse.

The recommended dosage is 30 mg, which is taken 1-3 hours before sexual intercourse.

Do not start treatment with a dosage of 60 mg. Increasing the dosage to 60 mg per dose (per day) is possible only if there was no effect from taking a dose of 30 mg and if the patient did not observe adverse reactions after taking the minimum dosage.

Keep in mind that the frequency and strength of side effects increase when taking a dosage of 60 mg.

Do not exceed the maximum dosage and frequency of intake – 1 time per day (24 hours).

If sexual intercourse is not expected on this day, then you do not need to take a pill.

The clinical need for continuation of therapy with this drug is assessed by the attending physician after the first 4 weeks of treatment, or at least after 6 doses taken.

Further consultations should be carried out at least once every six months.

Patients with mild severity of renal and hepatic failure do not require dose adjustment.

The drug is not indicated for patients older than 65 years of age.

Side effects

Patients who used Priligy reported the following side effects:

• depression, euphoria, mood changes, nervousness, anxiety, sleep disorders, bruxism, decreased sexual desire, anorgasmia;
• dizziness, headache, drowsiness, tremor, a violation of taste, sedation, sudden drowsiness;
• mydriasis, eye pain, visual disturbances;
• vertigo, ringing in the ears;
• skin hyperemia, hot flashes, hypotension, tachycardia, orthostatic hypertension, increased blood pressure;
• nasal congestion, dry mouth, nausea, vomiting, diarrhea, constipation, dyspepsia, flatulence, urge to defecate;
• rash on the skin, hyperhidrosis, itching, cold sweat;
• erectile dysfunction, impaired ejaculation, paresthesia in the male genital organs;
• allergy;
• weakness, fatigue, fever, anxiety, intoxication, withdrawal syndrome.

If you notice any unusual side effects, you should contact your doctor.

Interactions

Don’t take Priligy if you are currently using PDE5 inhibitors, such as sildenafil, tadalafil, avanafil or vardenafil.

Do not take any of the following drugs until 7 days after you have last taken Priligy:

• duloxetine;
• triptans for migraine, such as sumatriptan;
• linezolid;
• lithium;
• rasagiline;
• selegiline;
• monoamine oxidase inhibitor (MAOI) antidepressants, such as phenelzine, tranylcypromine, isocarboxazid, moclobemide;
• SSRI antidepressants, such as fluoxetine, paroxetine, sertraline;
• the herbal remedy St John’s wort;
• tricyclic antidepressants such as clomipramine or amitriptyline;
• tryptophan;
• thioridazine;
• tramadol;
• venlafaxine.

Use any of the following drugs with caution because they can intensify side effects:

• atazanavir;
• itraconazole;
• ketoconazole;
• ritonavir;
• saquinavir;
• telithromycin;
• nefazodone;
• nelfinavir.

Contraindications

Do not use this drug in the presence of diseases/conditions given below:

• hypersensitivity (allergy) to one of the components of the drug.
• heart failure;
• conduction disturbances of the heart (AV-blockade, sick sinus syndrome);
• coronary heart disease;
• valvular heart disease;
• hepatic and renal failure in moderate and severe;
• syncopal status in history;
• mental disorders (mania, severe depression) in history;
• use with CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, etc.), monoamine oxidase inhibitors, thioridazine, serotonin reuptake inhibitors, other
• drugs with a serotonergic effect.
• use with products containing ethanol (alcoholic, low-alcohol beverages).
• age under 18 years.

Pregnancy and breastfeeding

This drug is not used in the treatment of women.

Precautions

There are no data about an overdose of dapoxetine. Theoretically, overdosing can cause signs of poisoning – nausea, vomiting, tachycardia, tremor, agitation and fainting. Treatment: gastric lavage, intake of chelators, symptomatic treatment. Dialysis, hemodialysis, forced diuresis, hemoperfusion or blood transfusion are ineffective. There is no specific antidote.

Priligy has a slight or moderate effect on the ability to drive vehicles or other mechanisms. The medication can cause dizziness, impaired attention, fainting, blurred vision and drowsiness. Therefore, patients need to be warned about the need to avoid traumatic situations, including driving and maintenance mechanisms.

Special storage conditions are not required. Keep out of the reach of children.

Do not use the drug after the expiration date printed on the package.